Bio-Chelat Overview

Chemical poisoning with heavy metals rarely show typical symptoms, even when they exceed upper limits in the blood. However, they will contribute to the overall load and are reasons for medical complaints that are not easily apparent. This can often make a diagnosis much more difficult.

A method to reduce the chronically increased concentration of heavy metals such as mercury, lead, or cadmium to allowable limits without affecting the metabolism, essential mineral levels, serum levels, liver panel or impair intestinal function is of medical interest.

The well-known treatment for acute heavy metal toxicity using penicillamine, ethylenediamintetraacetate (EDTA), as well as other chelaters such as DMPS, DMSA, is associated with such high doses, that side effects are unavoidable. These potent pharmaceuticals cannot be taken for an extended period of time (Goodman & Gilman: "The Pharmacological Base of Therapeutics," 8th ed. New York, page 1607-08).

In chronic heavy metal toxicity, the body typically contains only traces of heavy metal. It is not possible to eliminate these traces with a few, highly concentrated dosages of complex chelators. The reason behind this is that the proteins present in sulfhydryl-groups (-SH-group) form highly complex bonds with heavy metal ions such as mercury, cadmium, or lead, for which pharmaceutically enhanced chelators such as EDTA must compete with. The removal of the heavy metal ions from the organic proteins will be easier when the complex forming bonds of the SH groups are lowered.

Bio-Chelat™ is a patented chelator used for the excretion and removal of heavy metal ions based on polyaminopoly-carbonic-acid and its’ physiologically digestable salts, including small amounts of an oxidative catalyzer.

Ethylendiamintetra-acetate (EDTA) and diethylenetriaminopenta-acetate are well suited as polyaminopoly-carbonic-acids. In an acid environment these chelators show a high affinity to form complex bonds with mercury, cadmium and lead, while the physiologically important ions such as magnesium and calcium do not.

Since the pH in the stomach and intestines is acid, with exception of some parts of the lower intestines, food containing magnesium and calcium are not bound, so the orally taken complex former (Bio-Chelat™) is completely available to bind with the heavy metal ions.

Metal ions bound to EDTA are not absorbed in the stomach-intestinal tract, but are completely excreted. Food and other sources containing heavy metal ions (air, water and mercury fumes from amalgam fillings) will be simultaneously eliminated, as well.

Because of the presence of an oxidative catalyst, the complex forming effects of EDTA are highly increased. The -SH group in the intestine is changed through the oxidation effect to SO3 2-groups. The newly formed protein will not form any complex bonds with mercury, lead or cadmium ions, therefore making the EDTA exclusively available for the above named heavy metal ions. There is an additional benefit associated with EDTA being administered in a very low homeopathic dosage.

Bio-Chelat™ is a liquid chelator, with physiological salts such as sodium chloride, calcium chloride, potassium chloride, sodium hydrogen carbonate, citrate and other buffered substances. It is possible to use this chelator in chronic heavy metal detoxification over a long period of time without any side effects. Despite the low concentration of its active ingredients, the heavy metal content in the body will be significantly reduced without affecting or having an impact on the patients’ normal physiology.

The mineral concentrations in the serum of calcium, magnesium, potassium, sodium and selenium ions are not influenced. In clinical trials, an insignificant decrease in the concentration of serum zinc and leucocytes was seen, as well as a minimal increase of serum levels of thrombocytes and gamma-glutamyl-transferase (GGT). The resulting values of lactate-dehydrogenase (LDH) and glutamate-oxalo-acetate-transaminse (GOT) demonstrate that the liver and intestinal functions are not influenced when taking Bio-Chelat™.

Based on the chemical laws of isotonicity, (equal osmotic pressure in a liquid solution), free heavy metal ions are pulled from the body into the stomach/ intestinal tract and excreted. Therefore Bio-Chelat™ enhances the electro-magnetic phenomenon by achieving a high concentration gradient that overcomes the blood-brain barrier and the mercury ions are excreted from the brain.

	Assessment of Bio-Chelat in the Relief of Heavy Metal Burdens

Heavy metal burdens as a harmful substance is becoming more and more frequent. This possibility should always be explored when patients present unclear symptoms. The usual chelation treatment, particular DMPS, necessitates the use of relatively high doses of this harmful substance in treatments over long periods, or intermittent therapy. For this reason it was desirable to look for a drug to achieve a reduced burden to excrete heavy metals.

Often, no typical symptoms are seen in chemical poisoning by heavy metals when increased limits are seen in the blood. In general, the diagnosis of a chronic heavy metal burden belongs to the most difficult tasks in medicine. Likewise, when a heavy metal burden is found, the treatment should be free of side effects, when given over a longer time period.

The intake of penicillamine, calcium-edetate, DMPS and others is necessary for the treatment of acute poisoning, occasionally even with high doses. A chronic heavy metal burden, particularly when multiple permissible limits are recognized, but yet no toxic blood concentration, is the therapeutic use in the recommended doses (Dr. Daunderer) because of possible side effects is not justified. It would be much more meaningful to strive for a treatment with lower side effects.

Pre-trials showed the effectiveness and no side effects of Bio-Chelat™ when the documented allowable limits of heavy metals in the blood are increased.

The statistical analysis of the pre-clinical studies showed the reliability of those experiences that were gathered (see the summary of the results which also demonstrate a neutrality toward physiological minerals such as calcium, magnesium, potassium, sodium and selenium).

Another clinical study confirmed the results of these pre-clinical investigations and was able to prove that the treatment with Bio-Chelat™ leads to such a strong reduction of the heavy metal concentration in the blood, coupled with a slight decrease of zinc and leucocytes, and slight increase of thrombocytes and Gamma-GT-values, respectively. The additional confirmation regarding the physiologic iron, magnesium, calcium, LDH and GOT values showed that the general burden, particular on the liver, blood, and intestines, was missing when being treated with Bio-Chelat™.

This is to say that the results, in regards to both clinical studies, show the effectiveness of the heavy metal detoxification, harmlessness of the therapeutically used solution and allows the subsequent analysis of Bio-Chelat™:

• Bio-Chelat™ is useful in the treatment of chronic heavy metal burden but should not be used in acute poisoning because of its mild effectiveness.
  
  
• It is therefore not necessary to use the prevalently used high doses of EDTA in chronic heavy metal burdens and tolerate their side effects. Bio-Chelat™ is a strongly diluted EDTA substance containing other buffered substances and is fully effective over the duration of time used and without any side-effects during the removal of the patient's heavy metal burden.
  
  
• The treatment is successful even when multiple permissible heavy metal limits in the blood are present.
• Contrary to typical treatments and results, physiologic mineral concentration in the blood of Ca, Mg, K, Na, Se or Fe were not affected. This is of significant importance when patients of specific age groups are treated (kids, old people, pregnant women).
  
  
• Clinically controlling additional parameters can demonstrate that Bio-Chelat™, even when used over multiple weeks (see clinical study), doesn't place a burden on the blood, liver or intestinal functions (see LDH results).
  
  
• Bio-Chelat™ can be recommended, not only because of its’ negligible food chemistry-like concentrations, but also because of its’ complete harmlessness when used in the elimination of chronic heavy metal burden.

No position is taken at this time on the possible relief on the immune system by the gentle Bio-Chelat™ treatment.